Who starts in goal is arguably the toughest shout the head coach has had make as boss, as he needs to decide between Gavin Bazunu and Alex Bass between the sticks.
Then there’s the formation. Does Cowley go with the midfield diamond again or switch back to a 4-2-3-1 formation?
There’s the debate over whether to continue with Arsenal’s Miguel Azeez, rest Louis Thompson and bring back the in-form Joe Morrell into the equation.
Don’t discount the significance of players returning to fitness against the Dons either.
We’ve used our nous and knowledge to come up with what we believe will be the way Cowley goes at Fratton Park tomorrow.
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1. Big calls
From left: Alex Bass, Danny Cowley, Joe Morrell and Gavin Bazunu Photo: JPIMedia
2. Gavin Bazunu
Such a close call with Alex Bass, but shone away on international duty with Republic of Ireland and that quality with the ball at feet could just tip it in the Manchester City man's favour. Photo: The News
3. Mahlon Romeo
Nailing down that right-back slot and no reason for that to change against the Dons. Photo: The News
4. Sean Raggett
The 'first name on the team-sheet' cliche was made for Raggett and his form this season. Photo: The News