The Royal Navy’s future flagship departed from her home at the naval base on Wednesday afternoon.
She was initially due to leave on Monday, however a Covid-19 outbreak among her crew pushed it back two days.
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Hundreds of people lined the harbour walls in Old Portsmouth to give the carrier a proper send off.
HMS Queen Elizabeth is continuing the preparations for her maiden operational mission in 2021.
She will return to Portsmouth next week to take on stores before departing again.
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17. HMS Queen Elizabeth
The Royal Navy aircraft carrier HMS Queen Elizabeth leaves Portsmouth. Picture: Andrew Matthews/PA Wire Photo: Andrew Matthews
18. HMS Queen Elizabeth
HMS Queen Elizabeth leaves Portsmouth on 9 September 2020. Pictured: View from Still & West Pub, Portsmouth of HMS QE. Picture: Habibur Rahman Photo: Habibur Rahman
19. HMS Queen Elizabeth
HMS Queen Elizabeth leaves Portsmouth on 9 September 2020. Pictured: View from Still & West Pub, Portsmouth of HMS QE. Picture: Habibur Rahman Photo: Habibur Rahman
20. HMS Queen Elizabeth
HMS Queen Elizabeth leaves Portsmouth on 9 September 2020. Pictured: View from Still & West Pub, Portsmouth of HMS QE. Picture: Habibur Rahman Photo: Habibur Rahman