As things stand, Pompey are sitting in sixth place with 65 points, but, in a tightly-packed division, a poor run of results in their final handful of matches could see them surrender their spot to one of the chasing pack over the course of the final six games.
But what are the data experts saying about how the League One table will finish?
We've take a look at the third-tier and every club's predicted position and points totals, according to data experts FiveThirtyEight. This is where Portsmouth and all their divisional rivals are tipped to finish:
21. 4th - Blackpool
The Tangerines are set to finish fourth and bag a spot in the play-offs with 77 projected points according to the data experts. Photo: Joe Portlock
22. 3rd - Sunderland
Sunderland are predicted to finish third in League One, just missing out on automatic promotion.The Black Cats will compete in the play-offs, according to the date experts, and are projected to finish on 82 points. Photo: Lewis Storey
23. 2nd - Peterborough United
Peterborough United are predicted to finish second in League One this season and will go up automatically with 88 points. Photo: Nathan Stirk
24. 1st - Hull City
Hull City are predicted to finish the season top of the table, gaining automatic promotion with 89 points and going up as League One champions. Photo: Ross Kinnaird