The Blues may be the league’s form side but it's a tough assignment as they take on the Tractor Boys, who are also in good form themselves under new boss Kieran McKenna.
McKenna’s men are unbeaten in eight and were touted as the division’s best side by Lincoln boss Michael Appleton, after his side were defeated 2-0 on Tuesday night.
Danny Cowley has to consider how best to contain the big spenders, who could afford to name the likes of Conor Chaplin, James Norwood, Joe Pigott and Macauley Bonne on the bench at Portman Road last time out.
There are Pompey selection considerations all over the pitch, including who starts at left wing-back and in the middle of midfield, but particularly who partners George Hirst up front.
Here’s how we think Cowley will go in Suffolk.
A message from the Editor, Mark Waldron
You can support our local team of expert Pompey writers by subscribing here for all the latest news from Fratton Park for less than 25p per week.
13. Sub 1: Ollie Webber
Got an international call-up on the horizon but set to continue as Bazunu's back-up for now. Photo: Portsmouth FC
14. Sub 2: Denver Hume
Pushing for a start and hasn't done a lot wrong when he's been in the side. Photo: The News
15. Sub 3: Liam Vincent
Looks sets to be on the bench for a while after his return to fitness. Photo: Portsmouth FC
16. Sub 4: Jay Mingi
Got that debut he's been waiting for and looks like a decent option to have on the bench. Photo: Rogan Thomson