Eighteen members of head coach John Mousinho’s new-look squad have already featured for the Blues in League One this term.
However, chances are the Blues will make minimal changes to the side that beat Leyton Orient 4-0 on Saturday – leaving the likes of Fratton favourite Ryley Towler unable to force his way back into the side.
Meanwhile, the game is likely to have come too soon for Paddy Lane, who have recovered from a foot injury.
Here’s how we think Pompey could line up against the Grecians.
9. Right-wing: Gavin Whyte
The Northern Irishman supplied the crosses for two of Pompey's four goals on Saturday at Brisbane Road, which puts him just three league assists behind last season's right-wing first-choice Owen Dale. Photo: Jason Brown
10. No10: Christian Saydee
The former Bournemouth and Shrewsbury man continued his impressive Pompey start with another eye-catching performance at Leyton Orient. That will surely give him the nod to start against Exeter. However, don't forget Alex Robertson is yet to be properly unleashed. Again - further evidence of the strength and depth in the Blues' ranks. Photo: Jason Brown
11. Left-wing: Anthony Scully
The former Wigan man had the bit between his teeth after his second-half introduction against the O's. Scully found himself on the bench and behind Abu Kamara in the pecking order at Brisbane Road. Expect those roles to be swapped against the Grecians. Photo: Jason Brown
12. Centre-forward: Colby Bishop
Last season's top scorer is up and running again after his first-half header against Leyton Orient. He'll be desperate to add to that goal against Exeter, with his last Fratton Park goal coming against Port Vale on March 25. Photo: Jason Brown