John Mousinho faces some big decisions, particularly in attacking areas as Myles Peart-Harris returns to fitness and the likes of Kusini Yengi push for includsion.
Here's how we think he'll line up as he takes on former Southampton boss Nathan Jones at The Valley.
5. CB: Conor Shaughnessy
Spoke this week about his happiness on and off the pitch - and you can see it in his performances. Photo: Jason Brown
6. LB Connor Ogilvie
If you're a Pompey man you're a signed up member of the Connor Ogilvie Appreciation Society. Form going both ways has been excellent. | National World
7. CM Marlon Pack
What a season this could be for the local boy, as his form goes from strength to strength at a crucial moment. | Jason Brown/ProSportsImages
8. CM Owen Moxon
Watershed moment for the new boy, as he came through tough opening against Reading to impress. Has to now use that second-half effort at Fratton as platform to kick on. | PA