The Blues boss ranks the current injury and unavailability the worst he’s know in his time at Fratton Park, with a huge swathe of key players sidelined.
Mousinho faces a test to put out a competitive side against Kieran McKenna’s men, with Conor Chaplin also unavailable as part of the terms of his Pompey loan.
Here’s how we think the Pompey boss will go, as he takes on the huge challenge of bouncing back from the New Year’s Day mauling at Bristol City.
9. RW: Harvey Blair
Need a big game from the winger with so many key attacking influences absent. Time to show he has what it takes to influence proceedings at Championship level. | Graham Hunt
10. ACM Adrian Segecic
Due a goal after seven appearances without hitting the back of the net, following the Sydney Cyclone's ferocious start to life in English football. Photo: Graham Hunt
11. LW Minhyeok Yang
No Murphy and no Lang opens the door for a start for the Spurs loanee after his late, late Charlton Athletic heroics. Photo: Graham Hunt
12. CF Makenzie Kirk
Will likely be asked to lead the line again in the absence of Colby Bishop and Thomas Waddingham's continuing injury absence - even if Mousinho believes he's not ready for a run of Championship starts. | Graham Hunt/ProSportsImages