Injuries have been a continuous problem at Fratton Park throughout the campaign, with John Mousinho missing key members of his squad at various points of the season.
The Blues currently have 12 players out of action, although Conor Shaughnessy is expected to ease concerns as he closes in on a return this weekend.
Pompey make the long-trip north to Lancashire on Saturday as they face relegation rivals Blackburn Rovers at Ewood Park.
Just one point separates the two sides who are both hovering above the danger zone, with a win for either outfit ensuring a huge step towards survival.
We’ve taken a look at the latest injury latest and expected return dates - from what we know - of the Blues’ current absentees.
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1. Pompey injury latest and expected returns
From left: Keshi Anderson, John Swift, Conor Shaughnessy, Makenzie Kirk. | The News.
2. Keshi Anderson
Anderson featured just twice since his January free-transfer arrival before picking up a hamstring injury in training just weeks into his stay. Mousinho is hopeful of having the winger back in the fold for the Blues’ trip to QPR at the end of the month but has admitted he could wait until after the international break. Expected return: QPR (March 21)/Norwich City (April 3). | Graham Hunt/ProSportsImages
3. Josh Murphy
Mousinho confirmed the worst possible news over Murphy’s situation following Saturday’s defeat to Hull City, with the 31-year-old expected to remain out for the rest of the season. A fractured metatarsal sustained in early-December means the dangerman will be forced to sit out the final two months of the campaign. The winger has featured just 14 times for Pompey this term. Expected return: Pre-season. | Ian Lyall/ProSportsImages
4. Conor Shaughnessy
Pompey will have one member of the injured cohort returning this weekend for their crucial showdown with relegation rivals Blackburn Rovers. The centre-back has been sidelined since early January with a quad issue, but will complete his comeback this Saturday. Expected return: Blackburn Rovers (March 7). | Stephen Flynn/ProSportsImages