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The Lilywhites have picked up some impressive wins against fancied sides so far in the Championship, and will offer a stern test of the credentials of John Mousinho’s side.
There’s some interesting selections calls for Mousinho to make with new faces building fitness and form also a big consideration.
Here’s how we think Pompey will go line up at PO4.
13. Sub 1 Ben Killip
Jordan Archer could go but Ben Killip is definitely staying as Schmid's immediate back-up. Photo: Paul Phelan
14. Sub 2 Josh Knight
New boy is ready for a place on the bench against Preston, after not making the West Brom squad. | Portsmouth FC
15. Sub 3: Jacob Farrell
Could well not make the squad like last week, but makes sense to have some specialist left-back cover and not two centre-backs on the bench. | Steve Bailey/ProSportsImages
16. Sub 4 Zak Swanson
Every chance he continues after West Brom in close call with Jordan Williams. Photo: Simon Roe