A daunting task awaits John Mousinho and his Pompey side as Premier League leaders Arsenal make the trip to Fratton Park.
The Gunners, who are the highest seed in the competition, visit PO4 for the first time in six years to face the Blues who are in the midst of an injury crisis.
Mousinho’s side, meanwhile, welcome Mikel Arteta’s side off the back of a 5-0 defeat to Bristol City on New Year’s Day after their game against Ipswich Town last week was postponed.
We’ve taken a look at the early team and injury news from both camps ahead of Sunday’s third-round tie.
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1. Pompey v Arsenal: Early team and injury news
Injury news from both camps ahead of Pompey's FA Cup tie against Arsenal on Sunday. | Graham Hunt/ProSportsImages
2. Connor Ogilvie - Out
There is light at the end of the tunnel for the left-back, who has missed more than two months of action due to a knee injury. Ogilvie is back in training and has been pencilled in to return against Watford on January 21. | Jez Tighe/ProSportsImages
3. Piero Hincapie - Out
The centre-back is set to undergo scans on a hamstring issue which was sustained in Thursday’s goalless draw with Liverpool. | Getty Images
4. Callum Lang - Out
The number 49 was in brilliant form before picking up a hamstring issue after the triumph against QPR on Boxing Day. Lang is set for a short spell out of the side as he recovers from his latest setback. | Graham Hunt/ProSportsImages