Michael Harriman gave the visitors a 12th-minute lead, before goals either side of half-time from Leon Maloney (39 minutes) and Marcus Harness (62) hand the Blues victory.
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9. Marcus Harness
Pompey v Northampton in the Leasing.com Trophy Picture: Sean Ryan | JPIMedia Photo: Sean Ryan
10. Leon Maloney scores
Portsmouth v Northampton: first-half pictures from Leasing.com Trophy | JPIMedia Photo: Sean Ryan
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11. Leon Maloney of Portsmouth celebrates his equaliser with Andy Cannon of Portsmouth during the Leasing.com Trophy second round match between Portsmouth v Northampton Town, played at Fratton Park, Portsmouth. 03 Dec 2019
Leon Maloney celebrates | JPIMedia Photo: Sean Ryan
12. Anton Walkes
Pompey v Northampton second half in Leasing.com Trophy Picture: Sean Ryan | JPIMedia Photo: Sean Ryan
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