Pompey travel to London Road to face automatic promotion chasing Peterborough United in the Sky Bet League One.
Both sides come in to the game having won in midweek though Pompey might be the fresher of the two sides. Portsmouth defeated Burton Albion 2-1 thanks to efforts from Kusini Yengi who has been called up to represent the Australia national team later this month.
The Posh have rediscovered their form as of late and beat Stevenage 3-1 at home on Wednesday night. Harrison Burrows, Jadel Katongo and Kwame Poku were all on target for Saturday's hosts.
Peterborough are just four points off of second and have a game in hand over Derby County and Bolton. Nine points separate league leaders Portsmouth and Peterborough in fourth with Barnsley in fifth just a point behind them. A win for Peterborough coupled with a defeat for Bolton this weekend could see them go in to third heading in to the international break.
Both clubs have had their matches next week postponed because of international call-ups, and so for those currently out with injuries then they will have time to recover. Portsmouth's injury list is extensive but the end of March could be at a time that we see several players return from their respective issues.
Back in September, Portsmouth claimed a 3-1 win over Peterborough. Ricky-Jade Jones opened the scoring for the visitors at Fratton Park but Colby Bishop, Abu Kamara and Regan Poole all netted to earn the victory, despite Joe Morrell's red card late on. Portsmouth haven't won at London Road since September 15, 2018. Ronan Curtis set up both goals with Oliver Hawkins and Jamal Lowe on target for Kenny Jackett's side that day.
In the midst of there being international call-ups this week, some players are unavailable for their country through injury. Here's the latest injury and team news ahead of kick-off.
9. Hector Kyprianou - out (continued)
Darren Ferguson said: "You can not get booked ten times in a season. You can not. We’ve got the best disciplinary record in the league and he’s been booked ten times, you can not do that. It’s not good enough. "I’m disappointed with his performance. I don’t know whether it was because it was his last game (to avoid getting a booking) and that’s affected his mentality or what. He was way off, he knows that himself. “He grew into the game and got better, I told him at half time, you’ve done it now and need to stop worrying about it." | Getty Images
10. Ben Stevenson - out
Sustained knee ligament damage in January and has missed two months. He's not expected to play at the weekend but will provide another option when the Easter football begins. Photo: Jason Brown
11. Ben Stevenson - out (continued)
John Mousinho said: "Ben Stevenson trained fully on Wednesday, which is another step in the right direction. We think Saturday would be too soon for him." Photo: Jason Brown
12. Tom Lowery - out
Tom Lowery suffered a hamstring injury in February. A knee injury in August put him on the shelf for six months and he's now expected to return at the end of March or the start of April. | Jason Brown/ProSportsImages