The Blues make the trip to Kenilworth Road to face relegation rivals Luton, with three points potentially lifting John Mousinho’s men 12 points clear of the bottom three.
The Fratton faithful quickly snapped up their away allocation, with Pompey looking to extend their recent run to four consecutive Championship wins.
However, the Blues have an increasing injury list, with Thomas Waddingham the latest to be sidelined, while Rob Atkinson and Hayden Matthews’ fitness issues will be made clear after this afternoon’s game.
Luton are yet to win under new boss Matt Bloomfield and currently prop-up the Championship table. The Hatters lost 2-0 against rivals Watford last week and now find themselves five points adrift of safety.
Here are the outs and doubts ahead of today’s fixture.
For your next Pompey read: Jordan Cross’ predicted Pompey team to face Luton
13. Mark O’Mahony - out
The striker, who scored against Oxford United a fortnight ago, was a surprise absentee against QPR last week due to a groin injury. It is unclear the extent of his injury and how long the Brighton loanee could be absent for. | Portsmouth FC
14. Mark McGuinness - doubt
Bloomfield revealed it will be touch and go whether the defender features and will face a last-minute fitness check as he returns from an ankle issue. | Getty Images
15. Isaac Hayden - doubt
The midfielder was withdrawn on the hour mark against QPR last week with an ankle issue but it remains to be seen if he is fit enough to return. Photo: Adam Fradgley
16. Zak Swanson - doubt
The right-back was another to have been withdrawn against QPR with a hamstring issue but, like others, it remains to be seen whether Swanson is fit to feature at Kenilworth Road. | Jason Brown/ProSportsImages