John Mousinho has confirmed he plans to make changes to his team, as he returns to his former club in the famous, old competition.
But to what extent does he switch things up at Adams Park? Jordan Cross has the inside track for you, as he names his expected team to feature against the League One high fliers.
13. Sub 1 Nicolas Schmid
A night on the bench for the keeper, who's been outstanding since arriving at Pompey in the summer. | Getty Images
14. Sub 2 Jordan Williams
Back in contention and a start on one side of the defence or the other isn't totally out of the equation. | National World
15. Sub 3 Ryley Towler
There are permutations which see Towler start and it's a close call whether he does with Rob Atkinson likely to go above him in the league pecking order. Photo: Jason Brown/ProSportsImages
16. Sub 4 Zak Swanson
Is now deemed a regular starter, so won't be in the starting XI for this one. Photo: Jason Brown