John Mousinho has confirmed he plans to make changes to his team, as he returns to his former club in the famous, old competition.
But to what extent does he switch things up at Adams Park? Jordan Cross has the inside track for you, as he names his expected team to feature against the League One high fliers.
5. CB Rob Atkinson
Really impressed in man-of-the-match cameo at Sunderland and will now have more of a chance to build match fitness. | National World
6. LB Connor Ogilvie
With news of the Jacob Farrell injury blow, Pompey's Mr Dependable could continue. Alternatively, there's a chance of shifting McIntyre across and playing Towler in the middle - or moving Jordan Williams over to the left. | National World
7. CM Abdoulaye Kamara
Could be a rare chance for the Borussia Dortmund signing to show what he's all about. The clamour has eased for his involvement after looking out of his depth off the bench at Derby. Photo: Jason Brown
8. CM Owen Moxon
Will be tasked with running midfield, with his future perhaps slightly under the spotlight with Isaac Hayden set to arrive. Photo: Jason Brown