Danny Cowley’s men come up against Fleetwood Town on Saturday afternoon, and will be aiming to get their promotion hopes off to a positive start with a win.
Last season, Pompey were held to a 0-0 draw by Shrewsbury Town in the opening match of the campaign, but how are they likely to get on this time around?
The boffins at Bookmakers.tv have been flicking back through the history books to see how every League One club have fared on their 10 most recent opening day outings, and we’ve compiled a league table showcasing the results.
Will it be a positive return to action in the third tier for Cowley’s side, or will it be disappointment at the first hurdle?
Click and scroll through the pages below to read our countdown of all the standings...
5. Cheltenham Town - 20th
Won: 2 Drawn: 3 Lost: 5 Goal Difference: -2 Points: 9 (Photo by Matthew Lewis/Getty Images) Photo: Matthew Lewis
6. Wimbledon - 19th
Won: 2 Drawn: 4 Lost: 4 Goal Difference: -4 Points: 10 (Photo by Jacques Feeney/Getty Images) Photo: Jacques Feeney
7. Shrewsbury Town - 18th
Won: 2 Drawn: 4 Lost: 4 Goal Difference: -2 Points: 10 (Photo by Naomi Baker/Getty Images) Photo: Naomi Baker
8. Bolton Wanderers - 17th
Won: 3 Drawn: 2 Lost: 5 Goal Difference: -3 Points: 11 (Photo by Steve Bardens/Getty Images) Photo: Steve Bardens