It is home to major names like Primark, Top Shop and many more.
However it has said goodbye to some big high street names over the years.
Here are some of the shops that used to call Commercial Road home and what they were replaced by.
Make sure to click through the full gallery!
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17. C&A
C& was a staple in Portsmouth's city centre for decades. It was the city's first big shop re-opened after the Second World War. Photo: Michael Scaddan
18. H&M - replaced C&A
H&M can now be found in the spot that was once occupied by C&A. Photo: JPIMedia
19. Marks and Spencer
Marks and Spencer use to have a store in Commercial Road, however it closed in 2018. Photo: Google Maps
20. Emtpy site
The site of the former M&S store currently remains empty in Commercial Road as of November 2020. Photo: JPIMedia
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