Indoor hospitality, including pubs, restaurants and cafes, have reopened.
Museums, theatres, cinemas, bowling alleys and other entertainment venues are also allowed to open again.
It is the first time in 2021 that they have been able to open, as the city was under tier four restrictions over Christmas prior to the start of the third lockdown.
We have had photographers out and about across Portsmouth and the surrounding towns today.
Here are some of our best photos.
Make sure to click through all the pages of the gallery.
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5. Shagl Osman, Katerina Vedmedovska and manager Khaled Sleman
Shagl Osman, Katerina Vedmedovska and manager Khaled Sleman excited to serve indoors in cafe Nut, North End, Portsmouth. Picture: Habibur Rahman Photo: habibur rahman
6. Southsea friends Ian Jones, Martin Hudson and Rupert Ronca
Southsea friends Ian Jones, Martin Hudson and Rupert Ronca Photo: Steve Deeks
7. Lisa Wadey hugs her mum Angela
Lisa Wadey hugs her mum Angela for the first time since lockdown restrictions were relaxed. Picture: Stuart Martin (220421-7042) Photo: Stuart Martin
8. Jojo Cheung, Ionica Suruianu and Lucy Sheppard
Jojo Cheung, 47, the owner of CrumbleJack, Fareham with staff, Ionica Suruianu and Lucy Sheppard. Picture: Habibur Rahman Photo: Habibur Rahman